I realize that I'm noting this a bit late, but Daria, the animated series from MTV, is out on DVD. The DVD includes full episodes and the two full length Daria movies. It is missing the music featured in the original Daria airings on MTV due to legal reasons, but it's still fantastic.
Not into the whole series, but need a quick Daria fix? You can just buy "Daria - Is It College Yet?" and "Daria - Is It Fall Yet?" on DVD. I recommend the whole series, though. I mean, really, who can resist Daria Morgendorffer, Quinn Morgenorffer, Jane Lane and Trent Lane in hours of animated madness?
Note: if you like Daria, you might also like Clone High or The Oblongs. Maybe The Critic or Beavis and Butthead as well. If you're an MTV fan in general, try the MTV20 Collection.